Publications

12. The Antimicrobial Lipopeptide Tridecaptin A1 Selectively Binds to Gram-Negative Lipid II

S. A. Cochrane, B. Findlay, A. Bakhtiary, J. Z. Acedo, W. M. Rodriguez-Lopez, P. Mercier and J. C. Vederas

Proc. Natl. Acad. Sci. USA 2016, 113, 11561

Publications figure showing the NMR solution structure of the tridecaptin A1:lipid II complex

Publications figure showing the NMR solution-structure of the tridecaptin A1:lipid II complex 

Recommended in F1000 Prime

 

11. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates

S. A. Cochrane and J. C. Vederas

Med. Res. Rev. 201636, 4

 

10. Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity Against Gram-Negative Bacteria

S. A. Cochrane, X. Li, S. He, M. Yu, M. Wu and J. C. Vederas

J. Med. Chem. 201558, 9779

Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity Against Gram-Negative Bacteria Table of Contents Entry

9. Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1

S. A. Cochrane, R. R. Surgenor, K. M. W. Khey and J. C. Vederas

Org. Lett. 201517, 5428

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1 Table of Contents Entry

8. Studies on Tridecaptin B1, a New Tridecaptin Analogue with Activity Against Multidrug Resistant Gram-Negative Bacteria

S. A. Cochrane, C. T. Lohans, M. J. Van Belkum, M. Bels, and J. C. Vederas

Org. Biomol. Chem. 201513, 6073

Studies on Tridecaptin B1, a New Tridecaptin Analogue with Activity Against Multidrug Resistant Gram-Negative Bacteria Table of Contents Entry

2015 OBC Hot Article

 

7. Molecular Cloning and Characterization of Drimenol Synthase from Valerian (Valeriana officinalis)

M. Kwon, S. A. Cochrane, J. C. Vederas, and D. K. Ro

FEBS Lett. 2014588, 4597

Publications figure of the proposed drimenol synthase mechanism

Publications figure showing proposed mechanism of drimenol synthase

 

6. Unacylated Tridecaptin A1 Acts as an Effective Sensitizer of Gram-Negative Bacteria to Other Antibiotics

S. A. Cochrane and J. C. Vederas

Int. J. Antimicrob. Agents 2014, 44, 493

 

5. Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane

S. A. Cochrane, B. Findlay, J. C. Vederas and E. S. Ratemi

ChemBioChem 201415, 1295

Key Residues in Octyl-tridecaptin A1 Analogs Linked to Stable Secondary Structure in the Membrane Table of Contents Entry

 

4. Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A1

S. A. Cochrane, C. T. Lohans, J. R. Brandelli, G. Mulvey, G. D. Armstrong and J. C. Vederas

J. Med. Chem. 2014,  57, 1127

Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A1 Table of Contents Entry

3. Biochemical, Structural and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni

C. T. Lohans, M. J. van Belkum, S. A. Cochrane, Z. Huang, C. S. Sit, L. M. McMullen and J. C. Vederas

ChemBioChem 2014, 15, 243

Publications figure showing putative tridecaptin A1 non-ribosomal peptide synthetase gene cluster

Publications figure showing putative tridecaptin A1 non-ribosomal peptide synthetase gene cluster

 

2. Investigation of the Ring-Closing Metathesis of Peptides in Water

S. A. Cochrane, Z. Huang and J. C. Vederas

Org. Biomol. Chem. 2013, 11, 630

Investigation of the Ring-Closing Metathesis of Peptides in Water Table of Contents EntryOBC Hot Article

 

1. Solid Supported Chemical Synthesis of Both Components of the Lantibiotic Lacticin 3147

W. Liu, A. S. H. Chan, H. Liu, S. A. Cochrane and J. C. Vederas

J. Am. Chem. Soc. 2011133, 14216

Solid Supported Chemical Synthesis of Both Components of the Lantibiotic Lacticin 3147 Table of Contents Entry

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